The victims include the mother, her three sons and three daughters.
The car in which the family was traveling, collided with a heavy truck which caused the death of six children on the spot.
The mother was rushed to the hospital but was pronounced dead on arrival at the emergency.
The driver of the car, who was the sole survivor, is reportedly in stable condition at Sabya general hospital.
The horrific accident prompted Transportation Minister Dr. Nabil Al-Amoudi to sack Jazan Roads director Mohammed Al-Hazmi and launch an inquiry involving other officials, Sabq news reported.